GWAS-related eQTLs across different cancer types
We identified 337,131 eQTLs that overlap with GWAS linkage disequilibrium (LD) regions (r² ≥ 0.5).
|
Cancer type
|
eQTL type
|
tagSNP
|
Gene position (hg19)
|
p-value
|
|||||||
|---|---|---|---|---|---|---|---|---|---|---|---|
| THCA | cis | rs1552244 | 1 | rs4269070 | chr3:10126083 | C3orf10 | chr3:10157333-10168873:+ | -0.2 | -4.19 | 3.33E-5 | Alzheimer's disease |
| THCA | cis | rs1552244 | 1 | rs4269070 | chr3:10126083 | VHL | chr3:10183319-10193744:+ | -0.19 | -4.37 | 1.54E-5 | Alzheimer's disease |
| THCA | cis | rs4422476 | 1 | rs4269248 | chr4:118650663 | NDST3 | chr4:118954773-119179786:+ | -0.25 | -4.79 | 2.27E-6 | Neutrophil count |
| THCA | cis | rs4905558 | 1 | rs4270096 | chr14:97315536 | VRK1 | chr14:97263684-97347950:+ | 0.17 | 3.87 | 0.000122 | Neutrophil count |
| THCA | cis | rs607541 | 1 | rs4270120 | chr15:45936234 | SPATA5L1 | chr15:45694519-45713614:+ | 0.3 | 4.92 | 1.21E-6 | Obesity-related traits |
| THCA | cis | rs2243480 | 1 | rs427044 | chr7:65508545 | CCT6P1 | chr7:65216092-65228661:+ | 0.39 | 6.25 | 9.2E-10 | Diabetic kidney disease |
| THCA | cis | rs2243480 | 1 | rs427044 | chr7:65508545 | CRCP | chr7:65579805-65619551:+ | -0.28 | -4.29 | 2.19E-5 | Diabetic kidney disease |
| THCA | cis | rs2243480 | 1 | rs427044 | chr7:65508545 | RABGEF1 | chr7:66093890-66276446:+ | 0.57 | 7.16 | 3.09E-12 | Diabetic kidney disease |
| THCA | cis | rs607541 | 1 | rs4271550 | chr15:45936266 | SPATA5L1 | chr15:45694519-45713614:+ | 0.3 | 4.85 | 1.7E-6 | Obesity-related traits |
| THCA | cis | rs7216064 | 1 | rs4271626 | chr17:65930133 | C17orf58 | chr17:65987218-65989765:- | 0.19 | 3.84 | 0.00014 | Lung adenocarcinoma;Lung cancer;EGFR mutation-positive lung adenocarcinoma |
| THCA | cis | rs9790314 | 1 | rs4273380 | chr3:160950314 | NMD3 | chr3:160939099-160971319:+ | -0.11 | -3.71 | 0.000231 | Morning vs. evening chronotype |
| THCA | cis | rs10862219 | 1 | rs4274254 | chr12:81458128 | ACSS3 | chr12:81471809-81649582:+ | 0.22 | 4.67 | 4.01E-6 | Neuroticism |
| THCA | cis | rs4509693 | 1 | rs4277047 | chr10:102499416 | FBXW4 | chr10:103370422-103454743:- | -0.17 | -3.35 | 0.000873 | Alzheimer's disease |
| THCA | cis | rs801193 | 1 | rs4279493 | chr7:66226620 | GUSB | chr7:65425675-65447246:- | 0.34 | 6.84 | 2.43E-11 | Aortic root size |
| THCA | cis | rs801193 | 1 | rs4279493 | chr7:66226620 | RABGEF1 | chr7:66093890-66276446:+ | 0.52 | 10.69 | 4.74E-24 | Aortic root size |